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• ITP should be suspected any time during pregnancy with isolated thrombocytopenia of less than 50,000/cu mm , esp. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. ( 2 , 5 – 8 ) The predictive value of the quantitative MAIPA for neonatal thrombocytopenia was reported by Bertrand et al.
1 Three large series involving together > 26 000 women suggest that its prevalence at the end of pregnancy is between 6.6% and 11.6%. ( 9 ) , in 2005, and results were confirmed by Killie et al., in 2008. Fujimura Y, Matsumoto M, Kokame K, et al. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother’s platelets and those of the baby. Br J Haematol 2009; 144:742.
TTP/HUS indicates … Causes of thrombocytopenia during pregnancy can be directly related to pregnancy, or be unrelated. Moreover, most pregnant women with ITP may have a history of thrombocytopenia prior to pregnancy or may present with other immune-mediated diseases. ITP in pregnancy • ITP occurs in 1 per 1000 to 1 per 10,000 pregnancies, accounting for approximately 3% of women who are thrombocytopenic at delivery. Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. Thrombocytopenia which need to be investigated are the following: thrombocytopenia known before pregnancy, thrombocytopenia occurring during the 1(st) and 2(nd) trimester, platelet count <75 G/l in the 3(rd) trimester or thrombocytopenia in case of pregnancy with complications. 28 References

There is a tendency for non-invasive monitoring during pregnancy, considering that 1.3% of fetal death cases per procedure and 5.5% cases per affected pregnancy were attributed to cordocentesis. Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients. Thrombocytopenia in pregnancy deserves special consideration because of the possible consequences on the fetus. Thrombocytopenia in pregnancy. Table 1. Clinical scenarios and most common causes of thrombocytopenia. Gestational thrombocytopenia Vs ITP 49. Thrombocytopenia, defined as a platelet count < 150 × 10 9 /L, is second only to anemia as the most common hematologic abnormality encountered during pregnancy. Average platelet counts are decreased during pregnancy, especially during the third trimester, and when this decrease is mild and otherwise unexplained it is termed gestational thrombocytopenia, the most common cause of thrombocytopenia during pregnancy… A structured approach to the diagnosis of thrombocytopenia involves an integration of clinical findings and appropriate support from the laboratory and other medical disciplines. Mild gestational thrombocytopenia is relatively frequent during normal pregnancy and has generally no consequences for either the mother or the fetus. UpTodate: Thrombocytopenia in Pregnancy.